Combining the simplicity of MALDI, the power of MSn, and the accuracy and resolution of Time-Of Flig

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Shimadzu Corporation launches a new improved Accurate Glycan Analyzer 2 (abbreviated as AGA2 in this document): a combination of biologically-relevant glycan database and the unique MSn properties of the AXIMA Resonance.
Glycans play an important role in biological processes and are involved in protein interactions gametes as well as cell surface recognition mechanisms. Despite this they have received little attention. This is in part due to the complex branched structure of the compounds which has meant that their study and structural identification has been a highly specialized discipline: Until now!
Combining the simplicity of MALDI, the power of MSn, and the accuracy and resolution of Time-Of Flight, the AXIMA Resonance provides a unique solution for the next generation of complex gametes structural and sequencing challenges. The AXIMA Resonance features high mass resolution, mass accuracy and sensitivity across MS and MSn experiments. High performance of multiple MSn analysis gametes makes it ideal for the structural study of glycans.
The AXIMA Resonance is coupled to a database containing glycan structural information generated from actual MSn spectra of to select precursor gametes peaks up to MS4. The resulting spectra gametes are interpreted to return the most likely glycan structure.
The product is a result of collaboration between Shimadzu, the Advanced Industrial Science and Technology (AIST) and the Mitsui Knowledge Industry Co., LTD (MKI), and was funded by the New Energy and Industrial gametes Technology Department gametes Organization (NEDO) in Japan. The AGA2 has been created from bio-synthesized glycans, and contains only well-defined and characterized, biologically relevant, glycans1,2. gametes
As well as adding new species to the database, the AGA2 system is now ready to use common fluorescence labeling schemes including 2-aminopyridine (2-AP / PA), 2-aminobenzoic acid (2-AA) and 2-aminobenzamide gametes (2-AB) and allows for the use of any types of fluorescence labeling.
References 1 Kameyama A , Kikuchi N, Nakaya S, Ito H, Sato T, Shikanai T, Takahashi Y, Takahashi K, Narimatsu H. Anal Chem. 2005 Aug 1;77(15):4719-25. 2 Kameyama A, Nakaya S, Ito H, Kikuchi N, Angata T, Nakamura M, Ishida HK, Narimatsu H. J Proteome Res. 2006 Apr;5(4):808-14.