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INTRODUCTION Mutations bioinformatics are changes in the genetic material of an organism that comes suddenly, randomly, and is fundamental to the sources of variation in living organisms inherited (congenital). Mutations can be seen in small numbers and small besar.mutasi cause only minor changes and sometimes not have a clear change of phenotypes, so it just kind of variation. major mutations cause major changes in phenotypes, normally regarded as abnormal or cacat.mutasi is because of changes bioinformatics that occur in a special environment. This may be caused by the properties that are not fixed and are always influenced by various factors both natural and artificial. For a species extinction is not necessary to adapt to the emergence of a change. Appearance of mutations is very rarely seen, it is due to: - A mutation that occurs bioinformatics in a gene, can not display appearance, because the number of genes contained in a single individual lot - A mutated gene is lethal so that the symptoms can not be observed because the mutated individual dies shortly before the adult - General mutated gene is recessive, so long as the conditions are not to be visible hetreozigot The term mutation was first used by Hugo de Vries, to express the phenotype of the sudden changes in the interest Oenothera lamarckiana and fall. Apparently the change is due to the departure of the chromosomes. Seth Wright were also reported bioinformatics in sheep mutation event types are short-leg Ancon and fall. Scientific research on the mutation bioinformatics is produced by Morgan (1910), making use of Drosophila melanogaster (fruit fly). Finally, Morgan student named Joseph Muller succeeded in his experiments bioinformatics on fruit flies, which found that the mutation made by the use of X-ray DISCUSSION Understanding Movements Mutations are changes in the genes or chromosomes from an individual who drops. bioinformatics Individuals who are called the mutant and the mutation causes a mutation called mutagens. There are two ways of gene mutations may occur, which is obtained by the parent and that during a person's life. Mutation derived from parent to child inherited mutations or germline mutations called. These mutations are called germline mutations, as there are in the egg and sperm cells, bioinformatics also called germ cells (sperm). Mutations bioinformatics occur only in the egg or sperm cells, or just after fertilization occurs, mutations are called bioinformatics de novo (new). The Novo mutations may explain genetic disorders that a child has a mutation in all cells, but do not have a family history of this disease. Mutations acquired (somatic) in the DNA of individual bioinformatics cells at some time during a person's life. These changes are usually caused by environmental factors, musalnya ultraviolet radiation from the sun, or can occur if there are errors in the copying of DNA during cell division. Acquired mutations in somatic cells (cells other than the egg and sperm cells) can not be transferred to the next generation. bioinformatics Mutations can occur in a single cell in the early embryo. When embryonic cells divide during growth and development, an individual bioinformatics will have some cells with the mutation and cells without genetic modification. This is called the mosaikisme. DNA sequence can be changed in various ways. Gene mutations varying bioinformatics effects on health depending on where the appearance and the presence or absence of essential changes in the protein. There are 2 mutation, ie gene mutation and chromosome mutation. bioinformatics gene mutations (point mutations). Gene mutation is a change in the genetic material (DNA or RNA), both at the level of gene sequences (point mutations) or chromosome level. Mutations on the chromosomal level is usually called variance. Mutations in genes can lead to the emergence of new alleles and the basis for the support of the evolution of the emergence of new variations on the species. Changes in the DNA base sequence will cause a change in the protein coded by gen.Contohnya, when the gene that codes for a mutated enzyme, the enzyme bioinformatics encoded by the mutated no inactivity or its activities are reduced as a result of changes in that