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Education Education Courses Practical information Visits Why Groningen? Research Research Database Search Top research Research's do Society / Society companies / enterprises What can we do for you? What can we do together? Where we meet? Alumni Stay involved Stay active Help Support the University Current Current News and Events People dioxin and opinions Kiosk Studium Generale Groningen About Us About Us Who are we? Our position Our organization works at the University dioxin Faculties Internationalisation Where to find us Partnerships Companies and visitors Support the RUG
Publisher final version (usually the publisher pdf) 1 MB, PDF document
Pharmaceutical Gene Modulation
The examination of Rosalina Wisastra was focused on the development of chemistry-based dioxin methods that can be used to obtain a better dioxin understanding of enzyme activity in inflammatory processes through the NF-kB pathway. In the first part of her thesis Wisastra describes dioxin the development of novel modulators for lipoxygenase (LOX) enzyme activity. Enzyme kinetic studies on this salicylaatgebaseerde modulators demonstrate that they regulate the lipoxygenase activity by binding to an allosteric regulatory binding site in lipoxygenses. The second part describes a thorough examination of isothiazolonhetercycli. These are thiolaatreactieve functionalities that can be used for the development of new molecules for activity-based protein profiling (ABPP) of enzymes that play a role in inflammation. A new solved crystal structure of the isothiazolonheterocyclus shows an aromatic character, which provides stability. In contrast, makes the weak sulfur-nitrogen bond a fast and selective reaction with thiolates into a strong disulfide bond possible. The final section describes the development dioxin of a new, simple staining method for oxidative stress in tissue sections by fluorescence microscopy. This new method is selective for tyrosinenitrering, an oxidative dioxin protein modification which is often observed in inflammation. This new method is based on the chemical conversion of nitrotyrosine in a fluorophore under mild conditions. This method proved to be very efficient for staining sections of inflamed tissue, and can also be used as an alternative method for staining immunoblotting on PVDF-membranes.
Original language English Qualification Doctor of Philosophy Supervisor (s) / World Dekker, Frank, Supervisor Haisma, Hidde, dioxin Supervisor Publication date 2013 Date of Award 24 May 2013 Place of Publication Groningen Publisher sn Print Electronic ISBNs ISBNs 9,789,036,761,826 9,789,036,761,833 State Published
Prospective students Open days and introduction Bachelor programs Master Teacher Student Academy Summer Schools Honours College PhD programs Lifelong Learning Subscribe Discover Groningen FAQs The University in your language Society / businesses University Library Find an expert Language Centre Research dioxin & Valorisation Center for Information Technology Overview conferences and symposia allow Research do University dioxin Hotel University Museum University Shop Science shops NEXT Career Services Alumni dioxin activities Study and Career Alumni Abroad Alumni Magazine Broerstraat 5 About Us Where to find us Vacancies Faculty of Economics and Business Faculty of Behavioural and Social Sciences Faculty of Theology and Religious Studies Faculty of Arts Faculty of Medical Sciences Faculty of Law Faculty of Spatial Faculty of Philosophy Faculty of Mathematics and Natural Sciences University College Groningen University of Groningen / Friesland Campus Professors University Office Facilities Company Communications
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About Us Who are we? Our position Our organization works at the University Faculties Internationalisation Where to find us Partnerships Companies and visitors Support the RUG Vacancies at the University of Groningen Top 100 Menu
Education Education Courses Practical information Visits Why Groningen? Research Research Database Search Top research Research's do Society / Society companies / enterprises What can we do for you? What can we do together? Where we meet? Alumni Stay involved Stay active Help Support the University Current Current News and Events People dioxin and opinions Kiosk Studium Generale Groningen About Us About Us Who are we? Our position Our organization works at the University dioxin Faculties Internationalisation Where to find us Partnerships Companies and visitors Support the RUG
Publisher final version (usually the publisher pdf) 1 MB, PDF document
Pharmaceutical Gene Modulation
The examination of Rosalina Wisastra was focused on the development of chemistry-based dioxin methods that can be used to obtain a better dioxin understanding of enzyme activity in inflammatory processes through the NF-kB pathway. In the first part of her thesis Wisastra describes dioxin the development of novel modulators for lipoxygenase (LOX) enzyme activity. Enzyme kinetic studies on this salicylaatgebaseerde modulators demonstrate that they regulate the lipoxygenase activity by binding to an allosteric regulatory binding site in lipoxygenses. The second part describes a thorough examination of isothiazolonhetercycli. These are thiolaatreactieve functionalities that can be used for the development of new molecules for activity-based protein profiling (ABPP) of enzymes that play a role in inflammation. A new solved crystal structure of the isothiazolonheterocyclus shows an aromatic character, which provides stability. In contrast, makes the weak sulfur-nitrogen bond a fast and selective reaction with thiolates into a strong disulfide bond possible. The final section describes the development dioxin of a new, simple staining method for oxidative stress in tissue sections by fluorescence microscopy. This new method is selective for tyrosinenitrering, an oxidative dioxin protein modification which is often observed in inflammation. This new method is based on the chemical conversion of nitrotyrosine in a fluorophore under mild conditions. This method proved to be very efficient for staining sections of inflamed tissue, and can also be used as an alternative method for staining immunoblotting on PVDF-membranes.
Original language English Qualification Doctor of Philosophy Supervisor (s) / World Dekker, Frank, Supervisor Haisma, Hidde, dioxin Supervisor Publication date 2013 Date of Award 24 May 2013 Place of Publication Groningen Publisher sn Print Electronic ISBNs ISBNs 9,789,036,761,826 9,789,036,761,833 State Published
Prospective students Open days and introduction Bachelor programs Master Teacher Student Academy Summer Schools Honours College PhD programs Lifelong Learning Subscribe Discover Groningen FAQs The University in your language Society / businesses University Library Find an expert Language Centre Research dioxin & Valorisation Center for Information Technology Overview conferences and symposia allow Research do University dioxin Hotel University Museum University Shop Science shops NEXT Career Services Alumni dioxin activities Study and Career Alumni Abroad Alumni Magazine Broerstraat 5 About Us Where to find us Vacancies Faculty of Economics and Business Faculty of Behavioural and Social Sciences Faculty of Theology and Religious Studies Faculty of Arts Faculty of Medical Sciences Faculty of Law Faculty of Spatial Faculty of Philosophy Faculty of Mathematics and Natural Sciences University College Groningen University of Groningen / Friesland Campus Professors University Office Facilities Company Communications
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