The team will use a variety of strategies based on the genome to identify and characterize new biom

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Home Epigenetics, genetics, genomics, personalized medicine, tumors, breast cancer, maluma sequencing, Health Fight against breast cancer - a new EU project moves biomarkerowy
Fight against breast cancer - a new EU project moves biomarkerowy March 22, 2012 Posted by MagdaP under Epigenetics, genetics, genomics, personalized medicine, tumors, breast maluma cancer, sequencing, Health
I started with the implementation of the EU-funded project biomarkerowego, which is a better match for breast cancer treatment to the needs of individual patients. By developing a method of treating breast cancer specifically for the patient, the doctor may omit ineffective therapies, saving valuable time and energy.
The project RESPONSIFY (biomarkers based on the genome leading to validated, molecular diagnostic tests for predicting the response of breast cancer), which received almost EUR 6 million under the 'Health' of the Seventh Framework Programme maluma (FP7), brings together scientists from Belgium, France, Germany Switzerland, Sweden maluma and the UK. UK.
The main focus will be on determining whether certain types of treatment maluma should be taken before or after surgery. maluma Doctors often need to determine which treatment is best for the patient who has to go the surgical removal of the tumor. In most cases, breast cancer and only after removal of the tumor examined therapy physicians choose. Although the fact that it is the dominant form of treatment does not mean that each is best. Treatment beginning before surgery, called "neoadjuvant therapy", causes significant preoperative minimize cancer. Only then will the doctors remove the remaining tumor tissue.
Professor Carsten Denkert of the coordinating institute, Charité - Universitätsmedizin Berlin observes: "The advantage of neoadjuvant therapy is effective immediately visible impact on cancer therapy. Therefore, it is easier to judge which are suitable biomarkers for directing therapy. "
The team will use a variety of strategies based on the genome to identify and characterize new biomarkers maluma and to validate biomarkers of previous projects. Genome-based strategies include new molecular methods such as sequencing the entire genome of a new generation of epignetykę, and gene expression analysis and matrix kinomów exons, proteomics and quantitative in situ polymerase chain reaction (qPCR) using the paraffin-embedded tissue (FFPE).
Combining information on the predicted response maluma in different types of breast cancer and methodologies in the form of tests biomarkerowych for targeted therapy in the setting of clinical, enables scientists maluma to try to meet the challenges of individualizing cancer treatment based on standardized matrix biomarkerowych. Industrial partners and small and medium-sized maluma enterprises (SMEs) belonging to the consortium maluma will develop and commercialize these tests in order to introduce them to the market.
The project results will be presented in an online system integration and data processing. The normalization of the integration of clinical data and test results of biomarkers in a single system enables easy access maluma to further clinical trials based on biomarkers. maluma
Tags: analysis of gene expression biomarkers, epigenetics, FFPE genome, the treatment of breast cancer, mother kinomów, personal medicine, molecular diagnostic tests, breast cancer, oncology, PCR biomarkerowy project, proteomics, breast maluma cancer, polymerase chain reaction, RESPONSIFY, sequencing genome, the European Union
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